2,6-Dithiopurine Blocks Toxicity and Mutagenesis in Human Skin Cells Exposed to Sulfur Mustard Analogues, 2-Chloroethyl Ethyl Sulfide and 2-Chloroethyl Methyl Sulfide
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منابع مشابه
A Mouse Model of Acute and Delayed Complications of Sulfur Mustard Analogue, 2-Chloroethyl Ethyl Sulfide
Background: Numerous studies have been conducted on humans, animals, and cell cultures exposed to Sulfur Mustard (SM). However, the precise mechanism and cause or long-term pattern of SM injuries are not well defined. There is no protocol available for treating people with severe eye, lung, and skin ailments. The current study aimed to develop an animal model of the acute and delayed complicati...
متن کاملAirway tissue factor-dependent coagulation activity in response to sulfur mustard analog 2-chloroethyl ethyl sulfide.
Acute lung injury is a principal cause of morbidity and mortality in response to mustard gas (SM) inhalation. Obstructive, fibrin-containing airway casts have recently been reported in a rat inhalation model employing the SM analog 2-chloroethyl ethyl sulfide (CEES). The present study was designed to identify the mechanism(s) causing activation of the coagulation cascade after CEES-induced airw...
متن کاملSynthesis of MgO Nanoparticales and Identificationof Their Destructive Reaction Products by 2-Chloroethyl Ethyl Sulfide
Nanocrystalline magnesium oxides were prepared by sol–gel method and were characterized by X-ray diffraction, N2-BET, SEM and infrared spectroscopy techniques. The results confirmed the formation of Nano- MgO materials with crystallite size in range of 5-20 nm and surface areas of 336-556m2/g. The product has been tested as destructive adsorbent for the decontamination of (2-chloroethyl) et...
متن کاملSelective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells.
Thioredoxin reductase (TrxR) is a selenocysteine-containing flavoprotein that catalyzes the NADPH-dependent reduction of oxidized thioredoxin and plays a key role in regulating cellular redox homeostasis. In the present studies, we examined the effects of 2-chloroethyl ethyl sulfide (CEES), a model sulfur mustard vesicant, on TrxR in lung epithelial cells. We speculated that vesicant-induced al...
متن کاملsynthesis of mgo nanoparticales and identificationof their destructive reaction products by 2-chloroethyl ethyl sulfide
nanocrystalline magnesium oxides were prepared by sol–gel method and were characterized by x-ray diffraction, n2-bet, sem and infrared spectroscopy techniques. the results confirmed the formation of nano- mgo materials with crystallite size in range of 5-20 nm and surface areas of 336-556m2/g. the product has been tested as destructive adsorbent for the decontamination of (2-chloroethyl) ethyl ...
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ژورنال
عنوان ژورنال: Chemical Research in Toxicology
سال: 2010
ISSN: 0893-228X,1520-5010
DOI: 10.1021/tx9001918